Estrogen receptors and human disease: an update
نویسندگان
چکیده
منابع مشابه
Estrogen and Liver X Receptors in Human Disease
The nuclear hormone receptors (NRs) are a class of transcription factors that has attracted great interest due to their important roles in animal physiology and metabolism. Studies of knockout (KO) mouse models have indicated several pathophysiological conditions in which the NRs are involved. Four NRs, the estrogen receptors (ERs) α and β, and liver X receptors (LXRs) α and β, are studied in t...
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Estrogen might play an important role in the pathogenesis of diabetes mellitus type 2. Estrogens inhibit diabetes via distinct mechanisms particularly by reducing both hyperglycemia and plasma insulin levels. Estrogen exerts its physiological effects mainly through estrogen receptors including α and β types. Estrogen receptors are found in many tissues that participate in the pathogenesis of ty...
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Estrogen signalling is a balance between two closely related transcription factors (TFs), the estrogen receptors (ERα and ERβ), both of which bind to similar DNA element called estrogen response element (ERE). ERs do not function by themselves but require a number of co-regulatory proteins (SRC1, A1, NCoR) whose cell-speciûc expression elucidates some of the divergent cellular actions of estrog...
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The discovery of a second estrogen receptor (ER), designated ERbeta (NR3A2), has redefined our knowledge about the mechanisms underlying cellular signaling by estrogens and has broad implications for our understanding of regulation of estrogen-responsive tissues. Highly variable and even contrasting effects of estrogens in different tissues seem to be at least partially explained by different e...
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The action mechanisms of estrogen receptors (ER) have been studied due to their important functions in cellular growth and differentiation in several organs and tissues, either or not directly related to reproduction. As in other regulatory processes, the mechanisms of receptor-ligand binding are crucial to enable the action of the estrogen hormone that will ultimately produce effects in the ce...
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ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2012
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-012-0868-5